Brain Injury Rehabilitation Specialists


Research 

Collaborations and Publications

As leaders in brain injury rehabilitation, we are involved in a number of research projects throughout the year and we strive every day to share our expertise with persons served, families and the community. The following highlights the research project that our program and persons served have been involved in. 

 

The Disorders of Consciousness Scale (DOCS):  Administration and Clinical Application

On With Life served as a site for data collection as to the development of the Disorders of Consciousness Scale.  Persons served were assessed regularly and followed in order for the primary researchers to determine progress of clients over time, to examine for reliability and validity of the instrument, and specifically to examine the use of the instrument in persons with a Disorder of Consciousness as well as other persons served who were not presenting with a Disorder of Consciousness.  Data gathered went to the primary researcher, including for further use in research ventures.


Primary Investigator: Theresa Louise-Bender Pape, Dr.P.H.
Sponsoring Sites: Marianjoy Rehabilitation Hospital, Northwestern University, Edward Hines, Jr. Veterans Affairs Hospital


Incidence of Clinically Significant Responses to Zolpidem among Patients with Disorders of Consciousness

This study, ending in the publication noted, which has as an author On With Life's Director of Neuropsychology, Psychology, and Clinical Counseling Services and Research Coordinator (Dr. Demarest), involved serial study and assessmentof 6 On With Life human subjects/persons served following two research conditions:  (1) Administration of zolpidem (Ambien), a sleep-inducing medication, or (2) Placebo administration.  Zolpidem has shown a paradoxical effect in a portion of individuals who have diagnosed with a Disorder of Consciousness, and we have had one positive responder in the past at On With Life.  This study was part of a national effort through the sponsoring sites noted to research in a controlled way unlike previous research the effects of the zolpidem on restoration of responsiveness/consciousness.  The Coma Recovery Scale - Revised (CRS-R) was the primary assessment tool utilized.  All clinical assessments were completed by Dr. Demarest.


Primary Investigator: John Whyte, M.D., Ph.D.
Sponsoring Sites: Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network
Publication Associated with Research: Zolpidem and Restoration of Consciousness (2014).  Whyte, J., Rajan, R., Rosenbaum, A., Katz, D., Kalmar, K., Seel, R., Greenwald, B., Zafonte, R., Demarest, D., Brunner, R., & Kaelin, D.  American 
Journal of Physical Medicine and Rehabilitation, 93, 101-114.


Treatment Strategy to Prevent Mood Disorders following Traumatic Brain Injury

This study was an interventional study completed at On With Life, with assessments of persons served done on the Nursing unit by Nursing staff.  Mood and behavioral assessments were completed over the series of administration of the antidepressant medication, Zoloft, with data going to the primary researchers' database.  Antidepressant medication use has demonstrated, and not just related to improvement in mood status, benefit to recovery post-brain injury.


Primary Investigator: Ricardo Jorge, M.D.
Sponsoring Sites: University of Iowa Hospitals & Clinics


Amantadine and Repetitive Transcranial Magnetic Stimulation (rTMS) as a Neurotherapeutic for Disordered Consciousness after Traumatic Brain Injury

This study is investigating, in a sample of persons with traumatic brain injury who have had remote injury, the effectiveness of a medication which serves as a stimulant for persons recovering from injury (Amantadine), as well as the effects of an innovative and "cutting-edge" magnetic field intervention (rTMS) which has shown, and now in human subjects, greater improvements in cognitive recovery in a number of areas over time compared with a control group.  Treatment conditions are randomized and treatment will involve a subject from On With Life at Glenwood who presents with a Disorder of Consciousness.  This subject will be treated with Amantadine at our Glenwood facility and assessed for increased responsivity using, as a primary but not sole assessment instrument, the Disorders of Consciousness Scale (DOCS).  The subject will also be treated with the rTMS, and assessed for progress, at Northwestern University/Marianjoy Rehabilitation Hospital.

Primary Investigator: Theresa Pape, Dr.P.H.
Sponsoring Sites: Marianjoy Rehabilitation Hospital, Northwestern University, Edward Hines, Jr. Veterans Affairs Hospital


Repetitive Transcranial Magnetic Stimulation (rTMS) to Restore Function After Severe Traumatic Brain Injury

This project, upcoming in 2015, will involve On With Life subjects who have sustained severe traumatic brain injury and who are no more than one year post-injury, in order to examine the effect of rTMS, an innovative and "cutting-edge" magnetic field intervention which has shown, and now in human subjects, greater improvements in cognitive recovery in a number of areas over time compared with a control group.  Subjects will be transported to, treated, and assessed at Northwestern University/Marianjoy Rehabilitation Hospital.  Follow-up assessment by On With Life staff will occur following subjects' returns to OWL, with all follow-up data being provided to the primary researcher, Dr. Pape.  This study will involve a granteeship provided to OWL through the grant funding awarded to Dr. Pape and her team, under the aegis of On With Life's Director of Neuropsychology, Psychology, and Clinical Counseling Services and Research Coordinator (Dr. Demarest).


Primary Investigator: Theresa Pape, Dr.P.H.
Sponsoring Sites: Marianjoy Rehabilitation Hospital, Northwestern University, Edward Hines, Jr. Veterans Affairs Hospital

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